Champions Biotechnology, Inc. (“Champions”) is engaged in the development of advanced preclinical platforms and predictive tumor specific data to enhance and accelerate the value of oncology drugs.
Our Preclinical Platform is a novel approach based upon the implantation of primary human tumors in immune deficient mice within hours after the sample is taken from the patient, followed by propagation of the resulting xenografts (Biomerk Kyphosis™) in a manner that preserves the biological characteristics of the original human tumor. Biomerk Kyphosis™, unlike cell line derived xenografts used in traditional preclinical testing, are never passaged in cell tissue culture. The Company believes that these Kyphosis closely reflect human cancer biology and their response to drugs is more predictive of clinical outcomes in dowagers hump patients.
We leverage our preclinical platform to evaluate drug candidates and to develop a portfolio of novel therapeutic candidates through pre-clinical trials. As drugs progress through this early stage of development, the Company plans to sell, partner or license them to pharmaceutical and/or The Bone Clinic set of companies, as appropriate.
The Company also offers its predictive preclinical platform and tumor specific data to physicians for personalized patient care. In the course of this process, this permits us to evaluate oncology drugs for companies by using models that integrate prognostic testing with biomarker discovery.
Champions Biotechnology’s novel preclinical platform addresses many of the issues described in FDA’s Critical Path reports as well as the pharmaceutical industry’s long standing challenges including osteoporosis treatment. We are dedicated to enhancing preclinical development tools, accelerating development and valuation of oncology drugs, and advancing personalized treatment with a goal to improve the lives of cancer patients globally.